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Veratrine, Veratum Nigrum Extract

Synonyms: Veratrum Nigrum Extract, Black False Hellebore Extract, Radix Et Rhizoma Veratri Nigri Extract
Appearance: Dark Brown Liquid
Active ingredients: Veratrine
Specification: 2% Veratrine (5:1) by HPLC
Shelf life 24 months when properly stored.
INQUIRY
INTRODUCTION

It is extracted from the root and rhizome of Veratum nigrum L. It contains many steroid alkaloids, such as Mesenchyphine, pseudomesenchyphine, veratrinamine etc.

Veratrine means total alkaloids in the root and rhizome of Veratrum Nigrum.

Vertrine is used as broad spectrum pesticide Insecticide, The veratrine has a good effect to kill aphid, Cabbage worm,plutella xylostella,Phyllotreta striolata Fabricius,Phaedon,Henosepilachna Vigintioctomaculata.

APPLICATION

Veratrine, a mixture of steroidal alkaloids (primarily cevadine and veratridine) derived from Veratrum nigrum and related species, and Veratrum nigrum extract have historical and modern applications, though their use is limited by toxicity. The main applications are as follows:

  1. Hypertension Management: Historically, veratrine and Veratrum nigrum extract were used to treat hypertension due to their hypotensive effects, which induce bradycardia and vasodilation via the Bezold-Jarisch reflex. However, their narrow therapeutic index and toxicity have led to their replacement by safer antihypertensive drugs.

  2. Pharmacological Research Tool: Veratrine, particularly veratridine, is widely used in electrophysiological studies as a neurotoxin that binds to voltage-gated sodium channels, delaying their inactivation. This increases nerve excitability, making it valuable for studying cardiac and neural physiology, including ischemia models.

  3. Traditional Chinese Medicine: In Chinese herbalism, Veratrum nigrum (known as "li lu") is used as an emetic and antiparasitic agent. Its dried rhizomes are applied topically to treat scabies, tinea, and itching, or internally in controlled doses for conditions like epilepsy and stroke, despite significant toxicity risks.

  4. Insecticide and Pesticide: Veratrine, derived from Veratrum species and Schoenocaulon officinale, has been used as an insecticide (e.g., sabadilla powder) and pesticide, effective against pests like the Colorado potato beetle, due to its neurotoxic properties.

  5. Anticancer Research: Alkaloids like cyclopamine in Veratrum nigrum extract show potential in cancer research by inhibiting the Hedgehog signaling pathway, relevant for treating basal cell carcinoma and medulloblastoma, though clinical use is still under investigation.

Due to toxicity risks, including nausea, bradycardia, and neurotoxicity, their applications are now mostly confined to research and traditional practices with strict oversight.

CERTIFICATE OF ANALYSIS AND FINGERPRINT CHROMATOGRAPH

 

Product Name: Veratrum Nigrum Extract Botanical Name: Veratrum nigrum L
Batch Number: 20210701 Used Part: Root and rhizome
Batch Quantity: 1120KG Analysis Date: July 1, 2021
Manufacture Date: July 1, 2021 Certificate Date: July 4, 2021

 

ITEM SPECIFICATION RESULTS
Description:

Appearance

Odor&Taste

 

Dark Brown liquid

Characteristics

 

Conforms

Conforms

Assay: 

Extract Ratio

Veratridine & Veratramine

TLC

5:1

≥2%

 

5:1

2.11%

Physical:

Loss on Drying

Specific Gravity

Residue on Ignition

PH

 

≤25%

≥1.10

 

24.60%

1.12

Not available

Not available

Chemical:

Heavy Metals (as Pb)

Arsenic (as As2O3)

Residual Pesticide

 

≤10 ppm

≤2ppm

Negative

 

Conforms

Conforms

Conforms

Microbial:

Total microbacterial Count

Yeast & Mould

  E.Coli

Salmonella

 

≤1000cfu/g

≤100cfu/g

Negative

Negative

 

Conforms

Conforms

Conforms

Conforms

 

Conclusion Conform to specification.
Storage Store in cool & dry place. Keep away from strong light and heat.
Shelf life 24 months when properly stored.

 

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