INTRODUCTION
Phellodendron Bark (Cortex Phellodendri) is one of the fifty fundamental herbs of traditional Chinese medicine. Known also as Cortex Phellodendri, it is the bark of one of two species of Phellodendron tree: Phellodendron amurense or Phellodendron chinense.
Phellodendron amurense also called as Amur cork tree is originated in North of China, and Phellodendron chinense produce in South of China, mainly in Sichuan Province.
Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids.
Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) is a yellow crystal powder, no odour, extremely bitter, it can be soluble in hot water, and slightly soluble in water or ethanol. According to the solvent used in production, it can be reacted into Berberine hydrochloride and Berberine sulfate
APPLICATION
The bark is categorized in a traditional Chinese medicine counterpart of humorism, affecting the kidney, urinary bladder and large intestine meridians.
Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) has A natural broad-spectrum antibiotic inhabits pathogenic microorganisms, such as bacteria, fungi, and protozoa, for the treatment of many diseases.
Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) has antibacterial action on Gram-positive bacteria and Gram-negative bacteria, such as E. coli, pneumococcal, staphylococcus aureus, streptococcus, and salmonella typhi. Especially a strong antibacterial action on shigella dysenteriae, it also has some inhibitory effects on influenza virus, amoeba, leptospira and certain dermatophytes.
Berberine Sulfate (Berberine Sulphate, CAS NO. 6190-33-6, Molecular Formula:C40H42N2O15S) is usually used in veterinary product, it has good water solubility.
CERTIFICATE OF ANALYSIS AND FINGERPRINT CHROMATOGRAPH
ITEM |
SPECIFICATION |
RESULTS |
Description:
Appearance
Odor
Taste
Particle size
Extract Solvent |
Light Yellow crystalline Powder
Odorless
Extreme Bitter
100%pass 80 mesh sieve
Water &hydrochloric acid |
Conforms
ConfomsConforms
Confoms |
Assay:
Berberine HCL |
≥97%by Titration (CP2015) |
98.02% |
Physical:
Loss on Drying
Residue on ignition |
≤12.0 %
≤0.2 % |
10.80%
0.18% |
Chemical:
Heavy Metals
Arsenic(As)
Lead (Pb)
Mercury(Hg)Cadmium (Cd)
Solvent Residue
Methanol
Ethanol |
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm≤100ppm
≤500ppm |
Confoms
0.184ppm
0.022ppm
0.006ppm
0.012ppm2.18ppm
1.46ppm |
Microbial
Total Plate Count
Yeast &Mold
E.Coli
Salmonella spr
Staphylococcus aureus
Pseudomonas aeruginosa |
≤1000cfu/c
≤100cfu/gAbsent
Absent
Absent
Absent |
Conforms
Conforms
Conforms
Conforms
Confoms
Confoms |
ITEM |
SPECIFICATION |
RESULTS |
Description
Appearance
Odor
Taste
Particle size
Extract Solvent |
Yellow crystalline Powder
Odorless
Extreme Bitter
100%pass 80 mesh sieve
Water &Sulphate |
Confoms
Conforms
Confoms
Conforms
Confoms |
Assay:
Berberine Sulphate |
≥98%by Titration |
98.03% |
Physical:
Loss on Drying
Residue on ignition |
≤15.0 %
≤0.2 % |
14.02%
0.15% |
Chemical:
Heavy Metals
Arsenic (As)
Lead (Pb)
Mercury (Hg
Cadmium (Cd
Chloride |
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤40ppm |
Confoms
Confoms
Confoms
Confoms
Confoms
Conforms |
Microbial:
Total Plate Count
Yeast &Mold
E.Coli
Salmonella spp
Staphylococcus aureus
Pseudomonas aeruginosa |
≤1000cfu/ç
≤100cfu/g
Absent
Absent
Absent
Absent |
Conforms
Confoms
Confoms
Conforms
Confoms
Conforms |