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Cnidium Fruit Extract, Osthole, Cnidiadin

Synonyms: Fructus Cnidii Extract, Osthole, Cnidiadin
Appearance: Dark Brown liquid to Paste Brown Yellow to White Fine Powder
Active ingredients: Coumarins compounds (Osthole)
Specification: 10%-25% Osthole liquid to Paste
10%, 30%, 80%, 90%, 98% Osthole by HPLC
Shelf life 24 months when properly stored.
INQUIRY
INTRODUCTION

The main bioactivator compounds in Fructus Cnidii Extract are coumarins,which includes osthole, bergapten, isopimpinellin, columbianadin, archangelicin, edultin, O-acetylcolumianetin, O-isovalerycolumbianetin, cniforin A, xanthotoxol, xanthotoxin, imperatorin etc.

Osthole (CAS NO. 484-12-8, Molecular Formula: C15H16O3) also called as Osthol, is a kind of coumarins in the Fructus Cnidii Extract, which is extracted from the seed (Fructus Cnidii) of the plant “Cnidium monnieri (L.)Cuss.”.

Osthole has functions of Antifungus, Antivirus, anti-inflammatory, anesthetization and Enhancing Immune etc.

APPLICATION

1) Pharmaceutical field to stimulate sexual desire and enhance human immunity.

2) Cosmetic Field to Improve the pathological changes of psoriasis, with strong anti-inflammatory, anti-allergy, antipruritic effect

3) Osthole: A natural ingredient in botanical Pesticides & Bactericide (botanical source) to control diseases and pests:
A) It has inhibitory effect on gibberellum and Rhizoctonia solani of wheat.
B) As for cucumber and cabbage downy mildew, cucumber powdery mildew, apple leaf blight, orthomycosis and other plant pathogens Fungi, The Osthole has a broad spectrum of inhibitory activity.
C) Killing effect on the larval lepidoptera tea geometrid, plutella xylostella, rapeseed, the newly hatched noctuidae, aphid.

Osthole inhibits chitin deposition on insect body walls and fungal cell walls to show insecticidal and antibacterial activity. It can also inhibit the production, germination, adhesion, invasion and germ tube elongation of pathogenic fungi and act on the nervous system of pests.

The mechanism of action is to affect the growth of fungal cell walls, causing a large number of hyphae to break, and at the same time inhibiting the growth of pathogenic hyphae, preventing and treating various vegetable powdery mildew, downy mildew and other diseases.

The active ingredients act on the pest's nervous system, causing the insect's muscles to contract non-functionally, eventually leading to failure and death. This product has low toxicity and is easily decomposed in nature. It has good control effects on a variety of lepidopteran pests and homopteran pests, such as cabbage white butterfly, tea looper, cotton bollworm, beet armyworm, rice leaf roller, twenty-eight-spotted ladybird, and great ape leaf. A. Various aphids have good contact killing effect.

The application of osthole in agriculture, especially in insecticide and bactericidal, fruit and vegetable preservation and agricultural and livestock product preservation, etc. Since osthole exists in large amounts in Cnidoma monnieri extract, it is an extract from natural plants. It can be used as an insecticide and fungicide with a wide insecticidal and antibacterial spectrum, and it has good activity against E. coli. Ideal pesticides and fungicides in agriculture and ideal preservatives in food processing. It is more environmentally friendly than general chemical pesticides.

Apply during the peak hatching period. The effect is best when applied in the evening on sunny days and on cloudy days. It is highly toxic to silkworms and is banned in mulberry gardens. It is prohibited in seedling stage and legume crops. Do not mix with alkaline substances and copper preparations.

CERTIFICATE OF ANALYSIS AND FINGERPRINT CHROMATOGRAPH

 

CERTIFICATE OF ANALYSIS
Product Name: Cnidium  Fruit  Extract   Botanical Name:       Cnidium   monnieric(L.)Cuss
Batch Number: 20210510     Used Part:                 Fruit
Batch Quantity:        800KG                    Analysis Date:          May  15,2021
Manufacture Date:    May  10,2021             Certificate Date:       May  15,2021
ITEM SPECIFICATION RESULTS
Description

Appearance
Odor&Taste
Extract Solvent

Dark Brown Oleamen
Characteristics
Methanol &Water
Conforms
Confoms
Confoms
Assay:
Osthole
≥10%by HPLC 11.27%
Physical:
PH
Specific Gravity
6-8 7.20
1.03
Chemical:
Heavy Metals
Arsenic (As)
Lead (Pb)
Mercury (Hg
Cadmium (Cd)
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
Conforms

Confoms
Conforms
Conforms
Confoms

Microbial:
Total Plate Count
Yeast &Mold
E.Coli
Salmonella spp
Staphylococcus aureus
Pseudomonas aeruginosa
≤1000cfu/g
≤100cfu/gAbsent
Absent
Absent
Absent
Confoms
ConformsConforms
ConfomsConfomsConforms

 

CERTIFICATE OF ANALYSIS
Product Name Cnidium Fruit Extract Botanical Name:       Cnidium monnieric(L.)Cuss
Batch Number: 20210414 Used    Part:                     Fruit
Batch Quantity:        55KG                     Analysis Date:           April 19,2020
Manufacture Date:    April 14,2021             Certificate     Date:         April 19,2020
ITEM SPECIFICATION RESULTS
Description

Appearance
Odor&Taste
Extract Solvent

Dark Brown Oleamen
Characteristics
Methanol &Water
Conforms
Confoms
Confoms
Assay:
Osthole
≥20%by HPLC 22.86%
Physical:
PH
Specific Gravity
6-8
≥1.10
7.00
1.22
Chemical:
Heavy Metals
Arsenic  (As)
Lead  (Pb)
Mercury (Hg
Cadmium  (Cd)
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
Conforms

Confoms
Confoms
Conforms
Confoms

Microbial:
Total Plate Count
Yeast &Mold
E.Coli
Salmonella spp
Staphylococcus aureus
Pseudomonas aeruginosa
≤1000cfu/g
≤100cfu/gAbsent
Absent
Absent
Absent
Confoms
ConformsConforms
ConfomsConfoms
Conforms

 

CERTIFICATE OF ANALYSIS
Product Name Cnidium Fruit Extract Botanical Name:     Cnidium monnieric(L.)Cuss
Batch Number: 20210325 Used    Part:     Fruit
Batch Quantity: 150KG Analysis Date:     April  2,2021
Manufacture Date: March 25,2021 Certificate     Date:     April 2,2021
ITEM SPECIFICATION RESULTS
Description

Appearance
Odor&Taste
Particle size
Extract Solvent

Faint yellow fine Powder
Characteristics
100%pass 80 mesh sieveEthanol &Water
Conforms
Confoms
ConformsConforms
Assay
Osthole
≥90%by HPLC 90.39%
Physical:
Loss on Drying
Total Ash
≤5.0 %
≤5.0 %
0.52%
0.39%
Chemical:
Heavy Metals
Arsenic(As
Lead (Pb)
Mercury (Hg
Cadmium (Cd)
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
Conforms

Confoms
Confoms
Conforms

Conforms

Microbial:
Total Plate Count
Yeast &Mold
E.Coli
Salmonella sppStaphylococcus aureus
Pseudomonas aeruginosa
≤1000cfu/ç
≤100cfu/g
Absent
Absent
Absent
Absent
Conforms
ConformsConfoms
ConfomsConfoms
Conforms

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