INTRODUCTION
Milk Thistle, (also called as Silybum marianum(L.) Gaertn. or Carduus marianus L.), its seed contains a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others, Silibinin itself is a mixture of two diastereomers, silybin A and silybin B in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the fatty liver, non-alcoholic fatty liver, non-alcoholic steatohepatitis, the silymarin has the antioxidant, antiviral and anti-inflammatory properties
Milk Thistle Extract is extracted from the seed of the plant "Silybum marianum(L.) Gaertn. or Carduus marianus L." through different sovlents as Actone, Ethyl Acetate and Ethanol.
Silybin (Silibinin, Silybinin, CAS NO.22888-70-6, Mocular:C25H22O10) a natural polyphenolic flavonoid, is a major bioactive component of silymarin isolated from the plant milk thistle (Silybum marianum) that has been extensively used in treating hepatic ailments in Asia and Europe.
APPLICATION
1) Liver Protecting
The silymarin have reproductive function of hepatocytes to stimulate the new cells form; and also produce protective film on hepatocytes to precaution of viral penetration to hepatocytes. It is used in medicine of live protection, such as tablet, capsule.
2) Excellent Antioxidant
It can clear free radical in human body, postpone senility.
3) Preventing Arteriosclerosi
4) A natural feed additive against hepatotoxic effects of feed aflatoxins
Function of silymarin in Feed protects against hepatotoxic effects of feed aflatoxins, Mycotoxins not only reduce animal performance, but they also cause significant liver damage. The seeds of the herb plant milk thistle contain a mixture of flavonolignans known as silymarin and can help in reducing liver damage when animals get in contact with mycotoxin contaminated feed.
CERTIFICATE OF ANALYSIS AND FINGERPRINT CHROMATOGRAPH
ITEM |
SPECIFICATION |
RESULTS |
Description:
Appearance
Odor
Particle size
Extract Solvents |
Yellowish Brown Powder
Characteristic
100%pass 80 mesh sieve
Acetone and Hexane |
Conforms
Conforms
Conforms
Conforms |
Assay:
Silymarin
Silymarin calculated as Silybin (dry)
Silybins &Isosilybins |
≥80%by UV
by HPLC
≥30%by HPLC |
82.24%
49.54%
36.32% |
Physical:
Loss on Drying
Sulphated Ash |
≤5%
≤0.6% |
2.83%
0.21% |
Chemical:
Arsenic(As)
Lead (Pb)
Mercury(Hg
Cadmium (Cd)
Heavy Metals
Solvent Residue
HexaneAcetone |
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤20ppm≤290ppm
≤5000ppm |
Conforms
Conforms
ConformsConforms
Conforms
Conforms12ppm
3800ppm |
Microbial:
Total Plate Count
Yeast &Mold
F.Col
Salmonella
Staphylococcus
Aflatoxins |
≤1000cfu/g Max
≤100cfu/g Max
Negative
Negative
Negative
≤20ppm |
<10cfu/g
<10cfu/gConforms
Conforms
ConformsNon Detective |