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Milk Thistle Extract, Silymarin

Synonyms: Silybum Marianum Extract, Milk Thistle Seed Extract, Silybi Fructus Extract, Cardus Marianus Extract, Silymarin
Appearance: Orange Brown to White Fine Powder, Bitter
Active ingredients: a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others. Silybin also known as silibinin (Silybinin A + Silybinin B), Isosilybinin A, Isosilybinin B,
Specification: 70%-80% Silymarin
80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Actone
USP 50% Silymarin + 30% Silybin extracted by Actone
USP 60% Silymarin + 40% Silybin extracted by Actone
80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Ethyl Acetate
USP 50% Silymarin + 30% Silybin extracted by Ethyl Acetate
USP 55% Silymarin + 35% Silybin extracted by Ethyl Acetate
80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Ethanol
USP 50% Silymarin + 30% Silybin extracted by Ethanol
USP 55% Silymarin + 35% Silybin extracted by Ethanol
Water soluble 20%-40% Silymarin by UV
80%-99% Silybin by HPLC
Shelf life 24 months when properly stored.
INQUIRY
INTRODUCTION

Milk Thistle, (also called as Silybum marianum(L.) Gaertn. or Carduus marianus L.), its seed contains a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others, Silibinin itself is a mixture of two diastereomers, silybin A and silybin B in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the fatty liver, non-alcoholic fatty liver, non-alcoholic steatohepatitis, the silymarin has the antioxidant, antiviral and anti-inflammatory properties

Milk Thistle Extract is extracted from the seed of the plant "Silybum marianum(L.) Gaertn. or Carduus marianus L." through different sovlents as Actone, Ethyl Acetate and Ethanol.

Silybin (Silibinin, Silybinin, CAS NO.22888-70-6, Mocular:C25H22O10) a natural polyphenolic flavonoid, is a major bioactive component of silymarin isolated from the plant milk thistle (Silybum marianum) that has been extensively used in treating hepatic ailments in Asia and Europe.

APPLICATION

1) Liver Protecting
The silymarin have reproductive function of hepatocytes to stimulate the new cells form; and also produce protective film on hepatocytes to precaution of viral penetration to hepatocytes. It is used in medicine of live protection, such as tablet, capsule.

2) Excellent Antioxidant
It can clear free radical in human body, postpone senility.

3) Preventing Arteriosclerosi

4) A natural feed additive against hepatotoxic effects of feed aflatoxins
Function of silymarin in Feed protects against hepatotoxic effects of feed aflatoxins, Mycotoxins not only reduce animal performance, but they also cause significant liver damage. The seeds of the herb plant milk thistle contain a mixture of flavonolignans known as silymarin and can help in reducing liver damage when animals get in contact with mycotoxin contaminated feed.

CERTIFICATE OF ANALYSIS AND FINGERPRINT CHROMATOGRAPH
ITEM SPECIFICATION  RESULTS
Description:
Appearance
Odor
Particle size
Extract Solvents
Yellowish Brown Powder
Characteristic
100%pass 80 mesh sieve
Acetone and Hexane
Conforms

Conforms

Conforms
Conforms

Assay:
Silymarin
Silymarin calculated as Silybin (dry)
Silybins &Isosilybins
≥80%by UV
by HPLC
≥30%by HPLC
82.24%

49.54%
36.32%

Physical:
Loss on Drying
Sulphated Ash
≤5%
≤0.6%
2.83%

0.21%

Chemical:
Arsenic(As)
Lead (Pb)
Mercury(Hg
Cadmium (Cd)
Heavy Metals
Solvent Residue
HexaneAcetone
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤20ppm≤290ppm
≤5000ppm
Conforms
Conforms
ConformsConforms
Conforms
Conforms12ppm
3800ppm
Microbial:
Total Plate Count
Yeast &Mold
F.Col
Salmonella
Staphylococcus
Aflatoxins
≤1000cfu/g Max
≤100cfu/g Max
Negative
Negative
Negative
≤20ppm
<10cfu/g
<10cfu/gConforms
Conforms
ConformsNon Detective

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